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1.

Efficacy and safety of intravenous imatinib in COVID-19 ARDS: a randomized, double-blind, placebo-controlled clinical trial.

Atmowihardjo, Leila N; Schippers, Job R; Duijvelaar, Erik; Bartelink, Imke H; Bet, Pierre M; Swart, Noortje E L; van Rein, Nienke; Purdy, Keith; Cavalla, David; McElroy, Andrew; Fritchley, Sarah; Vonk Noordegraaf, Anton; Endeman, Henrik; van Velzen, Patricia; Koopmans, Matty; Bogaard, Harm Jan; Heunks, Leo; Juffermans, Nicole; Schultz, Marcus J; Tuinman, Pieter R; Bos, Lieuwe D J; Aman, Jurjan.

Crit Care; 27(1): 226, 2023 06 08.

Artículo en Inglés | MEDLINE | ID: mdl-37291677

2.

Respiratory Effects of the Atypical Tricyclic Antidepressant Tianeptine in Human Models of Opioid-induced Respiratory Depression.

Algera, Hyke; van der Schrier, Rutger; Cavalla, David; van Velzen, Monique; Roozekrans, Margot; McMorn, Alison; Snape, Michael; Horrigan, Joseph P; Evans, Stuart; Kiernan, Bernard; Sarton, Elise; Olofsen, Erik; Niesters, Marieke; Dahan, Albert.

Anesthesiology; 137(4): 446-458, 2022 10 01.

Artículo en Inglés | MEDLINE | ID: mdl-35867853

3.

The antidepressant tianeptine reverts synaptic AMPA receptor defects caused by deficiency of CDKL5.

Tramarin, Marco; Rusconi, Laura; Pizzamiglio, Lara; Barbiero, Isabella; Peroni, Diana; Scaramuzza, Linda; Guilliams, Tim; Cavalla, David; Antonucci, Flavia; Kilstrup-Nielsen, Charlotte.

Hum Mol Genet; 27(12): 2052-2063, 2018 06 15.

Artículo en Inglés | MEDLINE | ID: mdl-29618004

4.

Drug repurposing: Known knowns to unknown unknowns - Network analysis of the repurposome.

Cavalla, David; Crichton, Gamal.

Drug Discov Today; 28(7): 103639, 2023 07.

Artículo en Inglés | MEDLINE | ID: mdl-37236525

5.

The INVENT COVID trial: a structured protocol for a randomized controlled trial investigating the efficacy and safety of intravenous imatinib mesylate (Impentri®) in subjects with acute respiratory distress syndrome induced by COVID-19.

Atmowihardjo, Leila; Schippers, Job R; Bartelink, Imke H; Bet, Pierre M; van Rein, Nienke; Purdy, Keith; Cavalla, David; Comberiati, Valérie; McElroy, Andrew; Snape, Sue D; Bogaard, Harm Jan; Heunks, Leo; Juffermans, Nicole; Schultz, Marcus; Tuinman, Pieter R; Bos, Lieuwe D J; Aman, Jurjan.

Trials; 23(1): 158, 2022 Feb 16.

Artículo en Inglés | MEDLINE | ID: mdl-35172891

6.

Drug repurposing: progress, challenges and recommendations.

Pushpakom, Sudeep; Iorio, Francesco; Eyers, Patrick A; Escott, K Jane; Hopper, Shirley; Wells, Andrew; Doig, Andrew; Guilliams, Tim; Latimer, Joanna; McNamee, Christine; Norris, Alan; Sanseau, Philippe; Cavalla, David; Pirmohamed, Munir.

Nat Rev Drug Discov; 18(1): 41-58, 2019 01.

Artículo en Inglés | MEDLINE | ID: mdl-30310233

7.

Therapeutic switching: a new strategic approach to enhance R&D productivity.

Cavalla, David.

IDrugs; 8(11): 914-8, 2005 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-16254785

8.

Tianeptine prevents respiratory depression without affecting analgesic effect of opiates in conscious rats.

Cavalla, David; Chianelli, Fabio; Korsak, Alla; Hosford, Patrick S; Gourine, Alexander V; Marina, Nephtali.

Eur J Pharmacol; 761: 268-72, 2015 Aug 15.

Artículo en Inglés | MEDLINE | ID: mdl-26068549

9.

The extended pharmaceutical enterprise.

Cavalla, David.

Drug Discov Today; 8(6): 267-74, 2003 Mar 15.

Artículo en Inglés | MEDLINE | ID: mdl-12623241

10.

Predictive methods in drug repurposing: gold mine or just a bigger haystack?

Cavalla, David.

Drug Discov Today; 18(11-12): 523-32, 2013 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-23270784

11.

Retrospective clinical analysis for drug rescue: for new indications or stratified patient groups.

Cavalla, David; Singal, Chaim.

Drug Discov Today; 17(3-4): 104-9, 2012 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-22001144

12.

Does R&D pay?

Cavalla, David; Minhas, Raman.

Drug Discov Today; 15(5-6): 230-4, 2010 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-19931643

13.

Drug Repositioning and Off-Label Use-Finding the Balance and Understanding the Differences: Interview with David Cavalla, MA, PhD, Founder, Numedicus.

Cavalla, David; Persidis, Aris.

Assay Drug Dev Technol; 13(6): 294-6, 2015.

Artículo en Inglés | MEDLINE | ID: mdl-26241207

14.

A quiet revolution in lead optimisation services?

Cavalla, David.

Drug Discov Today; 9(15): 635-6, 2004 Aug 01.

Artículo en Inglés | MEDLINE | ID: mdl-15279844

15.

Biotechnology discovery productivity: a note of caution.

Cavalla, David.

Drug Discov Today; 8(21): 973-4, 2003 Nov 01.

Artículo en Inglés | MEDLINE | ID: mdl-14643158

16.

Getting more mileage out of a tankful of new molecular entities?

Cavalla, David.

Drug Discov Today; 9(7): 304-5, 2004 Apr 01.

Artículo en Inglés | MEDLINE | ID: mdl-15037227

17.

Web alert. The chemistry of biological products.

Cavalla, David.

Curr Opin Drug Discov Devel; 6(2): 157-8, 2003 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-12669448

18.

Web alert. The management of chemical and biological information.

Cavalla, David.

Curr Opin Drug Discov Devel; 6(3): 294-5, 2003 May.

Artículo en Inglés | MEDLINE | ID: mdl-12833659

19.

Web alert. The chemistry of biological products.

Cavalla, David.

Curr Opin Drug Discov Devel; 5(2): 189-90, 2002 Mar.

Artículo en Inglés | MEDLINE | ID: mdl-11926124

20.

Web alert. The chemistry of metabolic and toxicological processes.

Cavalla, David.

Curr Opin Drug Discov Devel; 5(1): 29-30, 2002 Jan.

Artículo en Inglés | MEDLINE | ID: mdl-11865670

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Efficacy and safety of intravenous imatinib in COVID-19 ARDS: a randomized, double-blind, placebo-controlled clinical trial.

Respiratory Effects of the Atypical Tricyclic Antidepressant Tianeptine in Human Models of Opioid-induced Respiratory Depression.

The antidepressant tianeptine reverts synaptic AMPA receptor defects caused by deficiency of CDKL5.

Drug repurposing: Known knowns to unknown unknowns - Network analysis of the repurposome.

The INVENT COVID trial: a structured protocol for a randomized controlled trial investigating the efficacy and safety of intravenous imatinib mesylate (Impentri®) in subjects with acute respiratory distress syndrome induced by COVID-19.

Drug repurposing: progress, challenges and recommendations.

Therapeutic switching: a new strategic approach to enhance R&D productivity.

Tianeptine prevents respiratory depression without affecting analgesic effect of opiates in conscious rats.

The extended pharmaceutical enterprise.

Predictive methods in drug repurposing: gold mine or just a bigger haystack?

Retrospective clinical analysis for drug rescue: for new indications or stratified patient groups.

Does R&D pay?

Drug Repositioning and Off-Label Use-Finding the Balance and Understanding the Differences: Interview with David Cavalla, MA, PhD, Founder, Numedicus.

A quiet revolution in lead optimisation services?

Biotechnology discovery productivity: a note of caution.

Getting more mileage out of a tankful of new molecular entities?

Web alert. The chemistry of biological products.

Web alert. The management of chemical and biological information.

Web alert. The chemistry of biological products.

Web alert. The chemistry of metabolic and toxicological processes.